TTG- IgA (Tissue Transglutaminase ) Test
Report Delivery Time: Next Day
Recommended Gender: Both
Sample Type: Blood
The TTG-IgA (Tissue Transglutaminase) Test is a highly accurate blood test used primarily to screen for celiac disease. It detects IgA antibodies against tissue transglutaminase, an enzyme involved in the autoimmune response triggered by gluten. This test is crucial for diagnosing gluten intolerance and initiating dietary and medical treatment. Early testing can help prevent long-term complications of undiagnosed celiac disease.
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The TTG-IgA (Tissue Transglutaminase) Test is a serological test that detects the presence of IgA antibodies directed against tissue transglutaminase (tTG), a key enzyme involved in the autoimmune reaction in individuals with celiac disease. It is considered the most sensitive and specific screening test for celiac disease.
Why is the Test Done?
This test is performed to:
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Diagnose celiac disease, an autoimmune condition triggered by gluten.
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Monitor how well individuals with celiac disease are responding to a gluten-free diet.
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Evaluate unexplained symptoms such as chronic diarrhea, weight loss, anemia, fatigue, or growth failure in children.
Who Should Get This TTG-IgA (Tissue Transglutaminase) Test?
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Individuals with symptoms of celiac disease such as bloating, gas, diarrhea, or fatigue.
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Children and adults with a family history of celiac disease.
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People with other autoimmune disorders (e.g., type 1 diabetes, thyroid disease).
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Patients experiencing nutrient deficiencies like iron, vitamin B12, or folate.
Test Procedure & Preparation
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Sample Required: Blood sample from a vein.
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Fasting: Not required.
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Preparation: The patient should be on a gluten-containing diet for several weeks before the test for accurate results.
This test measures the amount of TTG-IgA antibodies in the blood. High levels are indicative of an immune response associated with celiac disease.
Understanding the Results
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Positive: Elevated TTG-IgA antibodies suggest a high likelihood of celiac disease. A small intestinal biopsy may be recommended for confirmation.
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Negative: Indicates a low probability of celiac disease, especially if total IgA levels are normal.
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Note: In cases of IgA deficiency, the TTG-IgG test may be used as an alternative.
View more test and Health Checkup Packages: Hprime Labs Medical Tests
