Report Delivery Time: 3 Days
Recommended Gender: Both
Sample Type: Blood
The Calcitonin (Thyrocalcitonin) Test measures calcitonin levels in the blood, a hormone produced by the thyroid gland. It helps in diagnosing and monitoring medullary thyroid carcinoma (MTC) and detecting thyroid disorders and calcium metabolism issues.
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The Calcitonin Test measures the amount of calcitonin, a hormone secreted by the thyroid gland’s parafollicular C cells. Calcitonin plays a crucial role in regulating calcium levels in the blood by lowering calcium when it is too high.
This test is primarily used to diagnose and monitor medullary thyroid carcinoma (MTC), a rare thyroid cancer. It is also useful for detecting multiple endocrine neoplasia type 2 (MEN2) syndrome, which can lead to MTC and other endocrine disorders.
Why is the Test Done?
This test is recommended for:
✔ Diagnosing Medullary Thyroid Carcinoma (MTC) – A rare but aggressive thyroid cancer.
✔ Monitoring MTC progression and treatment effectiveness.
✔ Screening for Multiple Endocrine Neoplasia Type 2 (MEN2) – A genetic condition associated with MTC.
✔ Evaluating calcium metabolism disorders – Identifies abnormalities in calcium and bone health.
Who Should Get This Test?
This test is recommended for individuals who:
✔ Have a family history of medullary thyroid carcinoma (MTC).
✔ Show thyroid nodules or swelling with suspected MTC.
✔ Experience symptoms like neck lumps, difficulty swallowing, diarrhea, or flushing.
✔ Have elevated calcium levels or parathyroid disorders.
✔ Are diagnosed with Multiple Endocrine Neoplasia type 2 (MEN2).
Test Procedure & Preparation
Preparation:
- Fasting is usually not required.
- Avoid biotin supplements for 48 hours before testing, as they can interfere with results.
- Inform your doctor about any medications, especially calcium or proton pump inhibitors.
Procedure:
- A blood sample is drawn from a vein in your arm.
- The sample is analyzed using CLIA (Chemiluminescent Immunoassay) to measure calcitonin levels.
- Results are typically available within 1-3 days.
Understanding the Results
✔ Normal Range:
- Typically less than 10 pg/mL in men.
- Less than 5 pg/mL in women.
- Reference ranges may vary by laboratory.
✔ High Calcitonin Levels May Indicate:
- Medullary thyroid carcinoma (MTC).
- Multiple endocrine neoplasia type 2 (MEN2).
- Thyroid gland inflammation (thyroiditis).
- Chronic kidney disease (CKD).
- Lung or breast cancer (in rare cases).
✔ Low Calcitonin Levels:
- Generally not a concern unless there is a suspected underlying thyroid disorder.
⚠ A high calcitonin level does not confirm MTC. Further imaging and biopsy may be needed for diagnosis.
Limitations of the Test
❌ False positives may occur due to medications, kidney disease, or other conditions.
❌ Does not diagnose all thyroid cancers – Specific for MTC but not papillary or follicular thyroid cancer.
❌ Follow-up tests like RET gene mutation analysis may be required for genetic risk assessment.
Why is the Calcitonin Test Important?
✔ Early detection of medullary thyroid cancer (MTC) can lead to better treatment outcomes.
✔ Helps monitor treatment response in MTC patients.
✔ Assesses calcium metabolism disorders, aiding in managing parathyroid and bone health issues.
Timely calcitonin testing helps in early cancer detection and management, ensuring better prognosis and improved thyroid health.