Report Delivery Time: Next Day
Recommended Gender: Both
Sample Type: Blood
The C3 Complement Test measures the levels of Complement 3 (C3), a protein in the immune system that helps fight infections. This test is used to diagnose immune system disorders, autoimmune diseases, and infections such as lupus, rheumatoid arthritis, and recurrent bacterial infections.
₹600.00
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Email Address
info@hprimelabs.com
Email Address
customercare@hprimelabs.com
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The C3 Complement Test evaluates the levels of Complement 3 (C3) in the blood. C3 is a crucial component of the complement system, a group of proteins that help your immune system fight infections, clear damaged cells, and regulate inflammation. Abnormal C3 levels — either low or high — may indicate autoimmune disorders, infections, or inflammatory diseases.
Why is the C3 Complement Test Done?
The test is recommended to:
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Diagnose autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
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Monitor disease activity in people with known autoimmune conditions.
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Detect immune system deficiencies that can cause frequent infections.
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Evaluate complement system function in chronic inflammation cases.
Who Should Get the C3 Complement Test?
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Individuals showing symptoms of autoimmune disorders:
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Fatigue, joint pain, or swelling (common in lupus and RA)
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Skin rashes, especially the butterfly rash on the face (sign of lupus)
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Persistent infections or unexplained inflammation
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People with chronic infections that do not respond to treatment.
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Those with a family history of complement system disorders.
How is the C3 Complement Test Performed?
Preparation:
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No special preparation is generally required.
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Your doctor may advise avoiding medications that affect immune function.
Procedure:
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A blood sample is drawn from a vein in the arm.
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The sample is analyzed using Nephelometry, a precise method to measure protein concentration.
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Results are usually available within 24–48 hours.
Understanding the Results
| C3 Levels | Possible Indications |
|---|---|
| Normal Range | 75–175 mg/dL |
| Low C3 Levels | Autoimmune diseases (SLE, RA), chronic infections, complement deficiencies |
| High C3 Levels | Acute/chronic inflammation, infections, cancer |
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Low C3 levels are often a strong indicator of active lupus or other autoimmune conditions.
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High C3 levels can reflect acute infections, inflammation, or certain cancers.
Conditions Associated with Abnormal C3 Levels
Low C3 Levels:
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Systemic Lupus Erythematosus (SLE): C3 is consumed due to excessive immune activation.
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Rheumatoid Arthritis (RA): Inflammatory processes reduce complement levels.
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Chronic infections: Tuberculosis, bacterial sepsis, viral infections.
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Hereditary complement deficiencies: Genetic conditions causing recurrent infections.
High C3 Levels:
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Acute inflammation from infections or trauma.
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Certain cancers such as leukemia or lymphoma.
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Metabolic syndrome and cardiovascular diseases.
Limitations of the Test
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The C3 Complement Test cannot diagnose a specific disease; it helps assess overall immune activity.
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C3 levels alone are not enough; doctors may order a C4 Complement Test for a complete evaluation.
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Medications like corticosteroids and immunosuppressants may alter results.
Why is the C3 Complement Test Important?
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Helps in early diagnosis and monitoring of autoimmune diseases.
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Provides valuable insights into immune system health and infection risks.
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Guides treatment decisions in inflammatory and immune-related conditions.
Take Charge of Your Immune Health
The C3 Complement Test is a vital diagnostic tool for autoimmune diseases, chronic infections, and immune deficiencies. Early detection and accurate monitoring ensure timely medical intervention and effective disease management. Schedule your test today to stay proactive about your immune health.
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