Report Delivery Time: Next Day
Recommended Gender: Both
Sample Type: Blood
₹400.00
+919354028488
Email Address
info@hprimelabs.com
Email Address
customercare@hprimelabs.com
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The DCT (Direct Coombs Test), also known as the Direct Antiglobulin Test (DAT), is a laboratory test that detects antibodies or complement proteins that are already attached to the surface of red blood cells (RBCs).
These attached antibodies can cause the immune system to destroy RBCs, leading to hemolysis (breakdown of red blood cells).
Why is the Direct Coombs Test Done?
This test is performed to:
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Detect immune-mediated hemolytic anemia
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Evaluate transfusion reactions
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Diagnose autoimmune hemolytic anemia (AIHA)
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Detect hemolytic disease of the newborn (HDN) in newborn babies
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Investigate unexplained low hemoglobin or jaundice
What Does the Test Detect?
DCT finds:
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Antibodies (IgG) attached to RBCs
-
Complement proteins (C3) bound to RBCs
These substances indicate that the immune system is attacking the red blood cells.
Who Should Get This Test?
Doctors recommend DCT when a patient has:
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Sudden drop in hemoglobin
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Yellowing of skin or eyes (jaundice)
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Dark urine
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Symptoms of anemia
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Reaction after a blood transfusion
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Newborn showing signs of jaundice or anemia
Test Procedure
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A simple blood sample is taken from a vein (or heel prick for newborns).
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In the lab, a reagent called Coombs reagent is added to detect attached antibodies.
Understanding the Results
Positive DCT
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Antibodies are attached to RBCs.
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Suggests autoimmune hemolysis, transfusion reaction, drug-induced hemolysis, or HDN.
Negative DCT
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No antibodies detected on RBCs.
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Hemolysis (if present) may be due to non-immune causes.
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