Carbamazepine (Tegretol, Mazetol)
Report Delivery Time: Next Day
Recommended Gender: Both
Sample Type: Blood
The Carbamazepine Test measures the level of carbamazepine in the blood to ensure safe and effective treatment of epilepsy, bipolar disorder, and certain nerve pain conditions. It helps prevent toxicity and under-dosing in patients taking Tegretol, Mazetol, or other carbamazepine medications.
₹1,000.00
+919354028488
Email Address
info@hprimelabs.com
Email Address
customercare@hprimelabs.com
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The Carbamazepine Test is a therapeutic drug monitoring (TDM) test used to measure the concentration of carbamazepine, a medication prescribed for:
✔ Epilepsy and seizure disorders.
✔ Bipolar disorder (as a mood stabilizer).
✔ Neuropathic pain conditions, such as trigeminal neuralgia.
Since carbamazepine has a narrow therapeutic range, it is essential to monitor its blood levels to avoid toxicity or insufficient treatment effects.
Why is the Carbamazepine Test Done?
📌 To monitor drug levels and ensure they are within the therapeutic range.
📌 To prevent toxicity caused by high levels of carbamazepine.
📌 To check for under-dosing, which may lead to uncontrolled seizures or mood instability.
📌 To assess how the body is metabolizing the drug, especially in patients with liver disease.
📌 To detect drug interactions, as carbamazepine interacts with many other medications.
Who Should Get This Test?
🔹 Patients on long-term carbamazepine therapy for epilepsy, bipolar disorder, or neuropathic pain.
🔹 Individuals experiencing side effects, such as dizziness, nausea, or confusion.
🔹 Those with symptoms of toxicity, including:
- Blurred vision.
- Slurred speech.
- Unsteady movements (ataxia).
- Drowsiness.
- Severe skin reactions.
🔹 People starting or adjusting their carbamazepine dosage.
How is the Carbamazepine Test Performed?
Preparation:
- A fasting sample is not required, but the test is typically done just before the next scheduled dose (trough level) to get an accurate reading.
- Inform the doctor about any other medications being taken.
Procedure:
- A blood sample is drawn from a vein in the arm.
- The sample is analyzed using CLIA (Chemiluminescent Immunoassay).
- Results are usually available within 24-48 hours.
Understanding the Results
| Carbamazepine Level | Interpretation |
|---|---|
| 4-12 µg/mL (Therapeutic Range) | Safe and effective dosage |
| Below 4 µg/mL | Subtherapeutic – Risk of uncontrolled seizures or mood instability |
| Above 12 µg/mL | Toxic – Risk of serious side effects and complications |
⚠ Toxic levels can lead to:
- Confusion and dizziness.
- Heart rhythm abnormalities.
- Seizures (paradoxical effect).
- Liver or kidney damage.
Factors Affecting Carbamazepine Levels
🔸 Liver Function – Since the drug is metabolized in the liver, liver disease can cause accumulation.
🔸 Drug Interactions – Some medications increase or decrease carbamazepine levels (e.g., phenytoin, valproic acid, antibiotics).
🔸 Age & Metabolism – Children and some adults may metabolize the drug faster or slower.
🔸 Dose Adjustments – Frequent monitoring is required when changing doses.
Limitations of the Test
❌ Does not measure drug effectiveness – Symptoms should also be considered.
❌ Frequent monitoring may be needed for dose adjustments.
❌ Levels fluctuate based on metabolism and drug interactions.
Why is the Carbamazepine Test Important?
✔ Ensures safe and effective dosing.
✔ Prevents serious side effects and toxicity.
✔ Helps adjust medication for optimal treatment.
This test is essential for individuals on carbamazepine therapy to maintain seizure control, mood stability, and nerve pain relief while avoiding harmful side effects.
